Neuboron Medical Group, a leading global Accelerator-based Boron Neutron Capture Therapy  total solution provider, and Xiamen Humanity Hospital (XHH) collaborated to co-host the Xiamen BNCT Technology Forum 2023 at the BNCT center in XHH. The event agenda underscored various topics, including BNCT clinical research, molecular imaging, nuclear medicine, and the development of next-generation boron drugs. A group of distinguished speakers from renowned research institutions, such as Peking Union Medical College Hospital, Taipei Veterans General Hospital, West China Hospital of Sichuan University, Nanjing University, China Pharmaceutical University, Dalian University of Technology, Tamkang University, and Changhua University of Education, gathered in person to present their latest research findings. The conference was a hybrid event bringing together around 5,000 physical and virtual attendees to discuss the outlooking of BNCT's new drug and clinical development.

The first patient with recurrent head and neck chondrosarcoma at the forum shared his transformative experience with BNCT treatment. In addition, Prof. Dr. Yuan-Hao Liu of NMG presented the latest clinical research findings from the Xiamen BNCT center. To date, the Neuborons’ NeuPex AB-BNCT System, along with the use of boronophenylalanine (BPA) NBB-001, has demonstrated promising treatment efficacy and tolerable toxicity levels in 14 patients with 18 irradiations, particularly in controlling local tumors for head and neck (HN) patients, as well as demonstrating remarkable safety and efficacy for glioblastoma (GBM) patients. As of now, there have been a few cases where individuals have reached a complete response (CR).

The expansion of clinical indications for BNCT relies heavily on the development of new NCT drugs. Multiple research teams presented their latest findings on potential new compounds during the conference. These groups also carried out preclinical efficacy evaluation experiments on the Xiamen BNCT platform, which included cell and animal studies, in addition to fundamental pharmaceutical research. Their findings provided essential data for future clinical applications.

As a highly multidisciplinary advanced radiation modality, the forum marked an ideal platform for researchers to exchange their insightful perspectives on BNCT research. The Xiamen BNCT center strives to promote open innovation within the global BNCT community to accelerate the clinical application of BNCT research and novel drug development from bench to market in the short future.

Please note that the Neuborons' NeuPex AB-BNCT System and boron drugs are currently in development and are not available for commercial use.

Source:biospace.com