The American Urological Association (AUA) has unveiled the 2023 clinical practice guideline amendment for the diagnosis and treatment of early-stage testicular cancer.

Testicular cancer stands as the most prevalent solid malignancy among young males, albeit relatively rare. The outcomes in this context are contingent upon specific cancer and patient-related variables. A significant proportion of men diagnosed with testicular cancer present with low-stage disease, and conventional therapy yields high survival rates. For these patients, a primary concern is minimizing the impact of treatment and treatment-related side effects while maintaining effective cancer control.

This guideline underwent a rigorous evaluation process through the AUA Update Literature Review (ULR). Subsequently, it was modified in light of new literature, which includes the following key updates:

1. Incorporation of recent studies supporting the role of MRI in the surveillance and staging of patients with germ cell tumors.
2. Inclusion of retroperitoneal lymph node dissection as a treatment option for patients with stage IIA or IIB seminoma displaying a lymph node size of ≤3cm.
3. Revision of the guideline text to encompass long-term follow-up recommendations for patients with non-seminoma germ cell tumors who undergo 2 cycles of etoposide and cisplatin chemotherapy without bleomycin, and who exhibit pathological stage II disease that is not pure teratoma.
4. Introduction of new evidence advocating surveillance imaging for patients diagnosed with stage I testicular cancer.
5. Enhancement of the statement and expansion of content pertaining to survivorship.

Dr. Andrew Stephenson, Director of Urologic Oncology at Rush University Medical Center, emphasized the increasing importance of surveillance in the management of testicular cancer. He stated, "Surveillance has become more critical than ever for those with testicular cancer. Since the release of the last testicular cancer guideline, the management landscape has evolved significantly, underscoring the importance of this amendment in ensuring effective treatment and management of the condition."

It's worth noting that this amendment builds upon the 2019 guideline that initially addressed this topic. It underwent a thorough peer review process, involving reviewers from diverse backgrounds, before receiving approval from the AUA Board of Directors and the SUFU Executive Committee.

 

Source: prnewswire.com

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